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5lp6
From Proteopedia
(Difference between revisions)
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==Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex== | ==Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex== | ||
| - | <StructureSection load='5lp6' size='340' side='right' caption='[[5lp6]], [[Resolution|resolution]] 2.90Å' scene=''> | + | <StructureSection load='5lp6' size='340' side='right'caption='[[5lp6]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5lp6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[5lp6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LP6 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71P:~{N}-[(7~{R})-1,2,3-TRIMETHOXY-10-METHYLSULFANYL-9-OXIDANYLIDENE-6,7-DIHYDRO-5~{H}-BENZO[A]HEPTALEN-7-YL]ETHANAMIDE'>71P</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71P:~{N}-[(7~{R})-1,2,3-TRIMETHOXY-10-METHYLSULFANYL-9-OXIDANYLIDENE-6,7-DIHYDRO-5~{H}-BENZO[A]HEPTALEN-7-YL]ETHANAMIDE'>71P</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lp6 OCA], [http://pdbe.org/5lp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lp6 RCSB], [http://www.ebi.ac.uk/pdbsum/5lp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lp6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lp6 OCA], [http://pdbe.org/5lp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lp6 RCSB], [http://www.ebi.ac.uk/pdbsum/5lp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lp6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5lp6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5lp6" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Stathmin|Stathmin]] | ||
| + | *[[Tubulin|Tubulin]] | ||
| + | *[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]] | ||
| + | *[[User:Alisa Cario|User:Alisa Cario]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| + | [[Category: Buffalo rat]] | ||
| + | [[Category: Chick]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Aliverti, A]] | [[Category: Aliverti, A]] | ||
[[Category: Cappelletti, G]] | [[Category: Cappelletti, G]] | ||
Revision as of 06:22, 21 August 2019
Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex
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