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2ndh

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==NMR solution structure of MAL/TIRAP TIR domain (C116A)==
==NMR solution structure of MAL/TIRAP TIR domain (C116A)==
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<StructureSection load='2ndh' size='340' side='right' caption='[[2ndh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ndh' size='340' side='right'caption='[[2ndh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ndh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NDH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ndh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NDH FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yp2|2yp2]], [[3ub2|3ub2]], [[4lqd|4lqd]], [[4fz5|4fz5]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yp2|2yp2]], [[3ub2|3ub2]], [[4lqd|4lqd]], [[4fz5|4fz5]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ndh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndh OCA], [http://pdbe.org/2ndh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ndh RCSB], [http://www.ebi.ac.uk/pdbsum/2ndh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ndh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ndh OCA], [https://pdbe.org/2ndh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ndh RCSB], [https://www.ebi.ac.uk/pdbsum/2ndh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ndh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
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[[https://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2ndh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2ndh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Lavrencic, P]]
[[Category: Lavrencic, P]]
[[Category: Mobli, M]]
[[Category: Mobli, M]]
[[Category: Immune system]]
[[Category: Immune system]]

Revision as of 15:44, 8 June 2021

NMR solution structure of MAL/TIRAP TIR domain (C116A)

PDB ID 2ndh

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