3toj
From Proteopedia
(Difference between revisions)
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==Structure of the SPRY domain of human Ash2L== | ==Structure of the SPRY domain of human Ash2L== | ||
| - | <StructureSection load='3toj' size='340' side='right' caption='[[3toj]], [[Resolution|resolution]] 2.07Å' scene=''> | + | <StructureSection load='3toj' size='340' side='right'caption='[[3toj]], [[Resolution|resolution]] 2.07Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3toj]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3toj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TOJ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3toj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3toj OCA], [https://pdbe.org/3toj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3toj RCSB], [https://www.ebi.ac.uk/pdbsum/3toj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3toj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN]] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref> |
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| + | ==See Also== | ||
| + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Cao, F]] | [[Category: Cao, F]] | ||
[[Category: Chen, Y]] | [[Category: Chen, Y]] | ||
Revision as of 17:06, 6 July 2022
Structure of the SPRY domain of human Ash2L
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Categories: Human | Large Structures | Cao, F | Chen, Y | Dou, Y | Lei, M | Wan, B | Dpy-30 | Histone methylation | Histone methyltransferase | Nuclear | Protein binding | Rbbp5 | Spry domain | Transcription
