5x7d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:14, 18 October 2023) (edit) (undo)
 
Line 1: Line 1:
==Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist==
==Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist==
-
<StructureSection load='5x7d' size='340' side='right' caption='[[5x7d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='5x7d' size='340' side='right'caption='[[5x7d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5x7d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X7D FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5x7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X7D FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8VS:4-carbamoyl-N-[(2R)-2-cyclohexyl-2-phenylacetyl]-L-phenylalanyl-3-bromo-N-methyl-L-phenylalaninamide'>8VS</scene>, <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">e, T4Tp126 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8VS:4-carbamoyl-N-[(2R)-2-cyclohexyl-2-phenylacetyl]-L-phenylalanyl-3-bromo-N-methyl-L-phenylalaninamide'>8VS</scene>, <scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x7d OCA], [http://pdbe.org/5x7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x7d RCSB], [http://www.ebi.ac.uk/pdbsum/5x7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x7d ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x7d OCA], [https://pdbe.org/5x7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x7d RCSB], [https://www.ebi.ac.uk/pdbsum/5x7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
+
[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5x7d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x7d" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Escherichia virus T4]]
-
[[Category: Ahn, S]]
+
[[Category: Homo sapiens]]
-
[[Category: Chen, X]]
+
[[Category: Large Structures]]
-
[[Category: Dror, R O]]
+
[[Category: Ahn S]]
-
[[Category: Kahsai, A W]]
+
[[Category: Chen X]]
-
[[Category: Kobilka, B K]]
+
[[Category: Dror RO]]
-
[[Category: Latorraca, N R]]
+
[[Category: Kahsai AW]]
-
[[Category: Lefkowitz, R J]]
+
[[Category: Kobilka BK]]
-
[[Category: Liu, X]]
+
[[Category: Latorraca NR]]
-
[[Category: Masoudi, A]]
+
[[Category: Lefkowitz RJ]]
-
[[Category: Meng, K C]]
+
[[Category: Liu X]]
-
[[Category: Pani, B]]
+
[[Category: Masoudi A]]
-
[[Category: Venkatakrishnan, A J]]
+
[[Category: Meng K-C]]
-
[[Category: Weis, W I]]
+
[[Category: Pani B]]
-
[[Category: Gpcr]]
+
[[Category: Venkatakrishnan AJ]]
-
[[Category: Signaling protein]]
+
[[Category: Weis WI]]

Current revision

Structure of beta2 adrenoceptor bound to carazolol and an intracellular allosteric antagonist

PDB ID 5x7d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5x7d"
Personal tools