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5wcg
From Proteopedia
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==SET and MYND Domain Containing protein 2== | ==SET and MYND Domain Containing protein 2== | ||
| - | <StructureSection load='5wcg' size='340' side='right' caption='[[5wcg]], [[Resolution|resolution]] 2.02Å' scene=''> | + | <StructureSection load='5wcg' size='340' side='right'caption='[[5wcg]], [[Resolution|resolution]] 2.02Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5wcg]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5wcg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WCG FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A4M:[3-(6-amino-2-methyl-9H-purin-9-yl)azetidin-1-yl]{5-[(4-cycloheptylpiperazin-1-yl)methyl]-1-methyl-1H-pyrazol-3-yl}methanone'>A4M</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4M:[3-(6-amino-2-methyl-9H-purin-9-yl)azetidin-1-yl]{5-[(4-cycloheptylpiperazin-1-yl)methyl]-1-methyl-1H-pyrazol-3-yl}methanone'>A4M</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wcg OCA], [https://pdbe.org/5wcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wcg RCSB], [https://www.ebi.ac.uk/pdbsum/5wcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wcg ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bountra | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Brown | + | [[Category: Bountra C]] |
| - | [[Category: Casimiro-Garcia | + | [[Category: Brown PJ]] |
| - | [[Category: Dong | + | [[Category: Casimiro-Garcia A]] |
| - | [[Category: Edwards | + | [[Category: Dong A]] |
| - | [[Category: Hutch | + | [[Category: Edwards AM]] |
| - | [[Category: Kumpf | + | [[Category: Hutch A]] |
| - | [[Category: Owen | + | [[Category: Kumpf R]] |
| - | + | [[Category: Owen A]] | |
| - | [[Category: Seitova | + | [[Category: Seitova A]] |
| - | [[Category: Tatlock | + | [[Category: Tatlock J]] |
| - | [[Category: Taylor | + | [[Category: Taylor A]] |
| - | [[Category: Walker | + | [[Category: Walker JR]] |
| - | [[Category: Wu | + | [[Category: Wu H]] |
| - | [[Category: Zeng | + | [[Category: Zeng H]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
SET and MYND Domain Containing protein 2
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Brown PJ | Casimiro-Garcia A | Dong A | Edwards AM | Hutch A | Kumpf R | Owen A | Seitova A | Tatlock J | Taylor A | Walker JR | Wu H | Zeng H
