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5mfs

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==The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one==
==The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one==
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<StructureSection load='5mfs' size='340' side='right' caption='[[5mfs]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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<StructureSection load='5mfs' size='340' side='right'caption='[[5mfs]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mfs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MFS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mfs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MFS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7ML:[(7~{S})-6,6-BIS(OXIDANYL)-4-PHENYL-5,7,8,9-TETRAHYDROBENZO[7]ANNULEN-7-YL]AZANIUM'>7ML</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pepN, b0932, JW0915 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7ML:[(7~{S})-6,6-BIS(OXIDANYL)-4-PHENYL-5,7,8,9-TETRAHYDROBENZO[7]ANNULEN-7-YL]AZANIUM'>7ML</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mfs OCA], [https://pdbe.org/5mfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mfs RCSB], [https://www.ebi.ac.uk/pdbsum/5mfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mfs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mfs OCA], [http://pdbe.org/5mfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mfs RCSB], [http://www.ebi.ac.uk/pdbsum/5mfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mfs ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI]] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
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[https://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mfs" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mfs" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Membrane alanyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Albrecht, S]]
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[[Category: Albrecht S]]
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[[Category: Cavarelli, J]]
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[[Category: Cavarelli J]]
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[[Category: McEwen, A G]]
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[[Category: McEwen AG]]
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[[Category: Olieric, V]]
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[[Category: Olieric V]]
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[[Category: Peng, G]]
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[[Category: Peng G]]
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[[Category: Schmitt, C]]
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[[Category: Schmitt C]]
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[[Category: Tarnus, C]]
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[[Category: Tarnus C]]
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[[Category: Hydrolase]]
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[[Category: M1 aminopeptidase]]
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Current revision

The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

PDB ID 5mfs

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