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4drw

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==Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide==
==Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide==
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<StructureSection load='4drw' size='340' side='right' caption='[[4drw]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='4drw' size='340' side='right'caption='[[4drw]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4drw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DRW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4drw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DRW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100A10, ANX2LG, CAL1L, CLP11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drw OCA], [https://pdbe.org/4drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4drw RCSB], [https://www.ebi.ac.uk/pdbsum/4drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4drw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4drw OCA], [http://pdbe.org/4drw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4drw RCSB], [http://www.ebi.ac.uk/pdbsum/4drw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4drw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/S10AA_HUMAN S10AA_HUMAN]] Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. [[http://www.uniprot.org/uniprot/AHNK_HUMAN AHNK_HUMAN]] May be required for neuronal cell differentiation.
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[[https://www.uniprot.org/uniprot/S10AA_HUMAN S10AA_HUMAN]] Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.[[https://www.uniprot.org/uniprot/ANXA2_HUMAN ANXA2_HUMAN]] Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4drw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4drw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Junop, M S]]
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[[Category: Large Structures]]
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[[Category: Lee, T W]]
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[[Category: Junop MS]]
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[[Category: Rezvanpour, A]]
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[[Category: Lee T-W]]
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[[Category: Shaw, G S]]
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[[Category: Rezvanpour A]]
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[[Category: Atypical ef-hand]]
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[[Category: Shaw GS]]
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[[Category: Exocytosis-protein binding complex]]
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[[Category: Heteropentameric complex]]
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[[Category: Membrane repair]]
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Revision as of 08:36, 21 September 2022

Crystal Structure of the Ternary Complex between S100A10, an Annexin A2 N-terminal Peptide and an AHNAK Peptide

PDB ID 4drw

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