4oo9

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==Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant==
==Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant==
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<StructureSection load='4oo9' size='340' side='right' caption='[[4oo9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4oo9' size='340' side='right'caption='[[4oo9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oo9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OO9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oo9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OO9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2U8:MAVOGLURANT'>2U8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2U8:MAVOGLURANT'>2U8</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo9 OCA], [https://pdbe.org/4oo9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oo9 RCSB], [https://www.ebi.ac.uk/pdbsum/4oo9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo9 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRM5, GPRC1E, MGLUR5, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo9 OCA], [http://pdbe.org/4oo9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oo9 RCSB], [http://www.ebi.ac.uk/pdbsum/4oo9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN]] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.
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[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/GRM5_HUMAN GRM5_HUMAN] Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Escherichia virus T4]]
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[[Category: Lysozyme]]
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[[Category: Homo sapiens]]
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[[Category: Bennett, K]]
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[[Category: Large Structures]]
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[[Category: Cooke, R M]]
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[[Category: Bennett K]]
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[[Category: Dore, A S]]
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[[Category: Cooke RM]]
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[[Category: Errey, J C]]
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[[Category: Dore AS]]
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[[Category: Jazayeri, A]]
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[[Category: Errey JC]]
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[[Category: Khan, S]]
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[[Category: Jazayeri A]]
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[[Category: Marshall, F H]]
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[[Category: Khan S]]
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[[Category: Okrasa, K]]
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[[Category: Marshall FH]]
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[[Category: Patel, J C]]
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[[Category: Okrasa K]]
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[[Category: Serrano-Vega, M]]
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[[Category: Patel JC]]
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[[Category: Tehan, B]]
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[[Category: Serrano-Vega M]]
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[[Category: Weir, M]]
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[[Category: Tehan B]]
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[[Category: Wiggin, G R]]
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[[Category: Weir M]]
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[[Category: Cysteine-s-acetamide]]
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[[Category: Wiggin GR]]
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[[Category: G-protein]]
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[[Category: Membrane protein]]
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[[Category: Receptor]]
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Revision as of 07:35, 25 January 2023

Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant

PDB ID 4oo9

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