5vnp

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==X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand==
==X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand==
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<StructureSection load='5vnp' size='340' side='right' caption='[[5vnp]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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<StructureSection load='5vnp' size='340' side='right'caption='[[5vnp]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vnp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_mycoides_roseum"_grotenfelt_1889 "bacterium mycoides roseum" grotenfelt 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VNP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_rhodochrous Rhodococcus rhodochrous]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VNP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9FM:N-{2-[2-(hexyloxy)ethoxy]ethyl}-N~2~-methyl-N~2~-{[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl}glycinamide'>9FM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dhaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1829 "Bacterium mycoides roseum" Grotenfelt 1889])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9FM:N-{2-[2-(hexyloxy)ethoxy]ethyl}-N~2~-methyl-N~2~-{[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl}glycinamide'>9FM</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Haloalkane_dehalogenase Haloalkane dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.5 3.8.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vnp OCA], [https://pdbe.org/5vnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vnp RCSB], [https://www.ebi.ac.uk/pdbsum/5vnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vnp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vnp OCA], [http://pdbe.org/5vnp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vnp RCSB], [http://www.ebi.ac.uk/pdbsum/5vnp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vnp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHAA_RHORH DHAA_RHORH]] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Expresses halogenase activity against 1-chloroalkanes of chain length C3 to C10, and also shows a very weak activity with 1,2-dichloroethane.
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[https://www.uniprot.org/uniprot/DHAA_RHORH DHAA_RHORH] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Expresses halogenase activity against 1-chloroalkanes of chain length C3 to C10, and also shows a very weak activity with 1,2-dichloroethane.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5vnp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5vnp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacterium mycoides roseum grotenfelt 1889]]
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[[Category: Large Structures]]
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[[Category: Haloalkane dehalogenase]]
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[[Category: Rhodococcus rhodochrous]]
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[[Category: Boal, A K]]
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[[Category: Boal AK]]
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[[Category: Dunham, N P]]
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[[Category: Dunham NP]]
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[[Category: Biosensor]]
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[[Category: Cytotoxicity]]
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[[Category: Fluorescent probe]]
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[[Category: Hydrolase]]
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[[Category: Protein aggregation]]
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[[Category: Proteome stress]]
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Revision as of 13:52, 4 October 2023

X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand

PDB ID 5vnp

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