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5lst

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Current revision (18:46, 18 October 2023) (edit) (undo)
 
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==Crystal structure of the human RecQL4 helicase.==
==Crystal structure of the human RecQL4 helicase.==
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<StructureSection load='5lst' size='340' side='right' caption='[[5lst]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='5lst' size='340' side='right'caption='[[5lst]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lst]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LST FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lst]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LST FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RECQL4, RECQ4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lst OCA], [https://pdbe.org/5lst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lst RCSB], [https://www.ebi.ac.uk/pdbsum/5lst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lst ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lst OCA], [http://pdbe.org/5lst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lst RCSB], [http://www.ebi.ac.uk/pdbsum/5lst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lst ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN]] RAPADILINO syndrome;Baller-Gerold syndrome;Rothmund-Thomson syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN] RAPADILINO syndrome;Baller-Gerold syndrome;Rothmund-Thomson syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN]] DNA-dependent ATPase. May modulate chromosome segregation.<ref>PMID:15317757</ref>
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[https://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN] DNA-dependent ATPase. May modulate chromosome segregation.<ref>PMID:15317757</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lst" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lst" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Kaiser, S]]
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[[Category: Kaiser S]]
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[[Category: Kisker, C]]
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[[Category: Kisker C]]
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[[Category: Sauer, F]]
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[[Category: Sauer F]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Rapadilino-syndrome]]
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[[Category: Recq4]]
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[[Category: Rothmund-thomson-syndrome]]
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Current revision

Crystal structure of the human RecQL4 helicase.

PDB ID 5lst

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