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5uyz

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Current revision (13:37, 4 October 2023) (edit) (undo)
 
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==Structure of Human T-complex protein 1 subunit epsilon (CCT5) mutant His147Arg==
==Structure of Human T-complex protein 1 subunit epsilon (CCT5) mutant His147Arg==
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<StructureSection load='5uyz' size='340' side='right' caption='[[5uyz]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<StructureSection load='5uyz' size='340' side='right'caption='[[5uyz]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uyz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UYZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uyz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UYZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uyx|5uyx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCT5, CCTE, KIAA0098 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uyz OCA], [https://pdbe.org/5uyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uyz RCSB], [https://www.ebi.ac.uk/pdbsum/5uyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uyz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uyz OCA], [http://pdbe.org/5uyz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uyz RCSB], [http://www.ebi.ac.uk/pdbsum/5uyz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uyz ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TCPE_HUMAN TCPE_HUMAN]] Hereditary sensory and autonomic neuropathy with spastic paraplegia. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TCPE_HUMAN TCPE_HUMAN] Hereditary sensory and autonomic neuropathy with spastic paraplegia. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TCPE_HUMAN TCPE_HUMAN]] Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.<ref>PMID:20080638</ref>
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[https://www.uniprot.org/uniprot/TCPE_HUMAN TCPE_HUMAN] Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.<ref>PMID:20080638</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Adams, P D]]
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[[Category: Large Structures]]
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[[Category: King, J A]]
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[[Category: Adams PD]]
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[[Category: McAndrew, R P]]
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[[Category: King JA]]
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[[Category: Pereira, J H]]
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[[Category: McAndrew RP]]
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[[Category: Ralston, C Y]]
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[[Category: Pereira JH]]
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[[Category: Sergeeva, O A]]
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[[Category: Ralston CY]]
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[[Category: Chaperonin hexadecameric complex atp-dependent cct5 gene]]
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[[Category: Sergeeva OA]]
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[[Category: Protein binding]]
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Current revision

Structure of Human T-complex protein 1 subunit epsilon (CCT5) mutant His147Arg

PDB ID 5uyz

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