2b07

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2b07.gif|left|200px]]
[[Image:2b07.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2b07 |SIZE=350|CAPTION= <scene name='initialview01'>2b07</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_2b07", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=598:6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>598</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2b07| PDB=2b07 | SCENE= }}
-
|RELATEDENTRY=[[2azr|2AZR]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b07 OCA], [http://www.ebi.ac.uk/pdbsum/2b07 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b07 RCSB]</span>
+
-
}}
+
'''Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.'''
'''Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.'''
Line 41: Line 38:
[[Category: Xu, W X.]]
[[Category: Xu, W X.]]
[[Category: Zhang, Y L.]]
[[Category: Zhang, Y L.]]
-
[[Category: hydrolyase]]
+
[[Category: Hydrolyase]]
-
[[Category: protein tyrosine phosphatase]]
+
[[Category: Protein tyrosine phosphatase]]
-
[[Category: tricyclic thiophene]]
+
[[Category: Tricyclic thiophene]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:41:25 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:59:43 2008''
+

Revision as of 16:41, 3 May 2008

Image:2b07.gif

Template:STRUCTURE 2b07

Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.


Overview

A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.

About this Structure

2B07 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:16303309 Page seeded by OCA on Sat May 3 19:41:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b07"
Personal tools