2b2n

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[[Image:2b2n.gif|left|200px]]
[[Image:2b2n.gif|left|200px]]
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{{Structure
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|PDB= 2b2n |SIZE=350|CAPTION= <scene name='initialview01'>2b2n</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2b2n", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= mfd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_2b2n| PDB=2b2n | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2n OCA], [http://www.ebi.ac.uk/pdbsum/2b2n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b2n RCSB]</span>
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'''Structure of transcription-repair coupling factor'''
'''Structure of transcription-repair coupling factor'''
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[[Category: Lammens, A.]]
[[Category: Lammens, A.]]
[[Category: Wenig, K.]]
[[Category: Wenig, K.]]
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[[Category: rna polymerase]]
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[[Category: Rna polymerase]]
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[[Category: rnap]]
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[[Category: Rnap]]
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[[Category: strand-specific repair]]
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[[Category: Strand-specific repair]]
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[[Category: template strand]]
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[[Category: Template strand]]
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[[Category: uvra/b/c repair system]]
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[[Category: Uvra/b/c repair system]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:46:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:39 2008''
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Revision as of 16:46, 3 May 2008

Image:2b2n.gif

Template:STRUCTURE 2b2n

Structure of transcription-repair coupling factor


Overview

The transcription repair coupling factor Mfd removes stalled RNA polymerase from DNA lesions and links transcription to UvrABC-dependent nucleotide excision repair in prokaryotes. We report the 2.1A crystal structure of the UvrA-binding N terminus (residues 1-333) of Escherichia coli Mfd (Mfd-N). Remarkably, Mfd-N reveals a fold that resembles the three N-terminal domains of the repair enzyme UvrB. Domain 1A of Mfd adopts a typical RecA fold, domain 1B matches the damage-binding domain of the UvrB, and domain 2 highly resembles the implicated UvrA-binding domain of UvrB. However, Mfd apparently lacks a functional ATP-binding site and does not contain the DNA damage-binding motifs of UvrB. Thus, our results suggest that Mfd might form a UvrA recruitment factor at stalled transcription complexes that architecturally but not catalytically resembles UvrB.

About this Structure

2B2N is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs., Assenmacher N, Wenig K, Lammens A, Hopfner KP, J Mol Biol. 2006 Jan 27;355(4):675-83. Epub 2005 Nov 8. PMID:16309703 Page seeded by OCA on Sat May 3 19:46:22 2008

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