2b4c

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[[Image:2b4c.gif|left|200px]]
[[Image:2b4c.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b4c |SIZE=350|CAPTION= <scene name='initialview01'>2b4c</scene>, resolution 3.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2b4c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XYL:D-XYLITOL'>XYL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2b4c| PDB=2b4c | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4c OCA], [http://www.ebi.ac.uk/pdbsum/2b4c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b4c RCSB]</span>
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}}
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'''Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody'''
'''Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody'''
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[[Category: Wyatt, R.]]
[[Category: Wyatt, R.]]
[[Category: Zhang, M Y.]]
[[Category: Zhang, M Y.]]
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[[Category: cd4 induced antibody]]
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[[Category: Cd4 induced antibody]]
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[[Category: gp120]]
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[[Category: Gp120]]
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[[Category: hiv-1]]
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[[Category: Hiv-1]]
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[[Category: jrfl]]
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[[Category: Jrfl]]
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[[Category: v3]]
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[[Category: V3]]
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[[Category: x5]]
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[[Category: X5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:17 2008''
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Revision as of 16:50, 3 May 2008

Image:2b4c.gif

Template:STRUCTURE 2b4c

Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody


Overview

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.

About this Structure

2B4C is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of a V3-containing HIV-1 gp120 core., Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD, Science. 2005 Nov 11;310(5750):1025-8. PMID:16284180 Page seeded by OCA on Sat May 3 19:50:17 2008

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OCA

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