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| | ==Small heat shock protein AgsA from Salmonella typhimurium: C-terminal truncated construct== | | ==Small heat shock protein AgsA from Salmonella typhimurium: C-terminal truncated construct== |
| - | <StructureSection load='4zja' size='340' side='right' caption='[[4zja]], [[Resolution|resolution]] 4.10Å' scene=''> | + | <StructureSection load='4zja' size='340' side='right'caption='[[4zja]], [[Resolution|resolution]] 4.10Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4zja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4zja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJA FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zj9|4zj9]], [[4zjd|4zjd]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zja OCA], [https://pdbe.org/4zja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zja RCSB], [https://www.ebi.ac.uk/pdbsum/4zja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zja ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">agsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zja OCA], [http://pdbe.org/4zja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zja RCSB], [http://www.ebi.ac.uk/pdbsum/4zja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zja ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/D1MC98_SALTM D1MC98_SALTM] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus typhimurium loeffler 1892]] | + | [[Category: Large Structures]] |
| - | [[Category: Mani, N]] | + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] |
| - | [[Category: Suguna, K]] | + | [[Category: Mani N]] |
| - | [[Category: Chaperone]] | + | [[Category: Suguna K]] |
| - | [[Category: Crystallin]]
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| - | [[Category: Oligomer]]
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| - | [[Category: Small heat shock protein]]
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| Structural highlights
Function
D1MC98_SALTM
Publication Abstract from PubMed
Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions.
Multiple oligomeric structures of a bacterial small heat shock protein.,Mani N, Bhandari S, Moreno R, Hu L, Prasad BV, Suguna K Sci Rep. 2016 Apr 7;6:24019. doi: 10.1038/srep24019. PMID:27053150[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mani N, Bhandari S, Moreno R, Hu L, Prasad BV, Suguna K. Multiple oligomeric structures of a bacterial small heat shock protein. Sci Rep. 2016 Apr 7;6:24019. doi: 10.1038/srep24019. PMID:27053150 doi:http://dx.doi.org/10.1038/srep24019
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