2b52

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[[Image:2b52.gif|left|200px]]
[[Image:2b52.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b52 |SIZE=350|CAPTION= <scene name='initialview01'>2b52</scene>, resolution 1.88&Aring;
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The line below this paragraph, containing "STRUCTURE_2b52", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=D42:1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA'>D42</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2b52| PDB=2b52 | SCENE= }}
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|RELATEDENTRY=[[2b53|2B53]], [[2b54|2B54]], [[2b55|2B55]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b52 OCA], [http://www.ebi.ac.uk/pdbsum/2b52 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b52 RCSB]</span>
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}}
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'''Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562'''
'''Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Muckelbauer, J.]]
[[Category: Muckelbauer, J.]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: inhibition]]
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[[Category: Inhibition]]
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[[Category: mitosis]]
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[[Category: Mitosis]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:51:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:34 2008''
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Revision as of 16:51, 3 May 2008

Image:2b52.gif

Template:STRUCTURE 2b52

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562


Overview

New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.

About this Structure

2B52 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3., Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA, Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6. PMID:14698155 Page seeded by OCA on Sat May 3 19:51:56 2008

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OCA

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