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4z4m

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==Crystal structure of GFP-TAX1BP1 UBZ2 domain fusion protein==
==Crystal structure of GFP-TAX1BP1 UBZ2 domain fusion protein==
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<StructureSection load='4z4m' size='340' side='right' caption='[[4z4m]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4z4m' size='340' side='right'caption='[[4z4m]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z4m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeqvi Aeqvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z4M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z4m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z4M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR2:{(4Z)-2-(AMINOMETHYL)-4-[(4-HYDROXYPHENYL)METHYLIDENE]-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>CR2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR2:{(4Z)-2-(AMINOMETHYL)-4-[(4-HYDROXYPHENYL)METHYLIDENE]-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>CR2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z4m OCA], [https://pdbe.org/4z4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z4m RCSB], [https://www.ebi.ac.uk/pdbsum/4z4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z4m ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z4k|4z4k]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TAX1BP1, T6BP, PRO0105 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6100 AEQVI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z4m OCA], [http://pdbe.org/4z4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z4m RCSB], [http://www.ebi.ac.uk/pdbsum/4z4m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z4m ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI]] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
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[https://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4z4m" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4z4m" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aeqvi]]
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[[Category: Aequorea victoria]]
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[[Category: Kawasaki, M]]
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[[Category: Homo sapiens]]
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[[Category: Rohaim, A]]
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[[Category: Large Structures]]
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[[Category: Wakatsuki, S]]
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[[Category: Kawasaki M]]
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[[Category: Flurorescent protein]]
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[[Category: Rohaim A]]
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[[Category: Gfp]]
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[[Category: Wakatsuki S]]
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[[Category: Metal binding protein]]
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[[Category: Tax1bp1]]
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[[Category: Ubz]]
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[[Category: Zinc-finger]]
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Revision as of 07:39, 10 May 2023

Crystal structure of GFP-TAX1BP1 UBZ2 domain fusion protein

PDB ID 4z4m

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