2b5l

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[[Image:2b5l.gif|left|200px]]
[[Image:2b5l.gif|left|200px]]
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{{Structure
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|PDB= 2b5l |SIZE=350|CAPTION= <scene name='initialview01'>2b5l</scene>, resolution 2.85&Aring;
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The line below this paragraph, containing "STRUCTURE_2b5l", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|GENE= P/V ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5])
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|DOMAIN=
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{{STRUCTURE_2b5l| PDB=2b5l | SCENE= }}
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|RELATEDENTRY=[[2b5m|2B5M]], [[2b5n|2B5N]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b5l OCA], [http://www.ebi.ac.uk/pdbsum/2b5l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b5l RCSB]</span>
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'''Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein'''
'''Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein'''
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[[Category: Zheng, N.]]
[[Category: Zheng, N.]]
[[Category: Zhou, P.]]
[[Category: Zhou, P.]]
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[[Category: beta propeller]]
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[[Category: Beta propeller]]
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[[Category: ddb1]]
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[[Category: Ddb1]]
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[[Category: propeller cluster]]
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[[Category: Propeller cluster]]
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[[Category: sv5-v]]
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[[Category: Sv5-v]]
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[[Category: zinc finger]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:53:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:49 2008''
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Revision as of 16:53, 3 May 2008

Image:2b5l.gif

Template:STRUCTURE 2b5l

Crystal Structure of DDB1 In Complex with Simian Virus 5 V Protein


Overview

The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the V proteins of paramyxoviruses to degrade STATs and block interferon signaling. Here we report the crystal structures of DDB1 alone and in complex with the simian virus 5 V protein. The DDB1 structure reveals an intertwined three-propeller cluster, which contains two tightly coupled beta propellers with a large pocket in between and a third beta propeller flexibly attached on the side. The rigid double-propeller fold of DDB1 is targeted by the viral V protein, which inserts an entire helix into the double-propeller pocket, whereas the third propeller domain docks DDB1 to the N terminus of the Cul4A scaffold. Together, these results not only provide structural insights into how the virus hijacks the DDB1-Cul4A ubiquitin ligase but also establish a structural framework for understanding the multiple functions of DDB1 in the uniquely assembled cullin-RING E3 machinery.

About this Structure

2B5L is a Protein complex structure of sequences from Homo sapiens and Simian virus 5. Full crystallographic information is available from OCA.

Reference

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase., Li T, Chen X, Garbutt KC, Zhou P, Zheng N, Cell. 2006 Jan 13;124(1):105-17. PMID:16413485 Page seeded by OCA on Sat May 3 19:53:04 2008

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