4rk8

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==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356==
==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356==
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<StructureSection load='4rk8' size='340' side='right' caption='[[4rk8]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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<StructureSection load='4rk8' size='340' side='right'caption='[[4rk8]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rk8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RK8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rk8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RK8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3RV:5-FLUORO-2-{[(5Z)-5-(NAPHTHALEN-1-YLMETHYLIDENE)-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL]AMINO}BENZOIC+ACID'>3RV</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3RV:5-FLUORO-2-{[(5Z)-5-(NAPHTHALEN-1-YLMETHYLIDENE)-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL]AMINO}BENZOIC+ACID'>3RV</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rk8 OCA], [https://pdbe.org/4rk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rk8 RCSB], [https://www.ebi.ac.uk/pdbsum/4rk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rk8 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rk8 OCA], [http://pdbe.org/4rk8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rk8 RCSB], [http://www.ebi.ac.uk/pdbsum/4rk8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rk8 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
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[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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==See Also==
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Li, H]]
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[[Category: Large Structures]]
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[[Category: Ren, X]]
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[[Category: Li H]]
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[[Category: Zhu, J]]
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[[Category: Ren X]]
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[[Category: Zhu, L]]
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[[Category: Zhu J]]
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[[Category: Fmn binding]]
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[[Category: Zhu L]]
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[[Category: Mitochondria inner membrane]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Revision as of 07:00, 2 March 2023

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356

PDB ID 4rk8

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