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4yqd

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==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds==
==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds==
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<StructureSection load='4yqd' size='340' side='right' caption='[[4yqd]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='4yqd' size='340' side='right'caption='[[4yqd]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haein Haein]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GZ:6-{[(1-{2-[(3-METHYLBENZOYL)AMINO]ETHYL}CYCLOHEXYL)METHYL]AMINO}PYRIDINE-3-CARBOXAMIDE'>4GZ</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GZ:6-{[(1-{2-[(3-METHYLBENZOYL)AMINO]ETHYL}CYCLOHEXYL)METHYL]AMINO}PYRIDINE-3-CARBOXAMIDE'>4GZ</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ypw|4ypw]], [[4ypx|4ypx]], [[4ypz|4ypz]], [[4yq0|4yq0]], [[4yq1|4yq1]], [[4yq2|4yq2]], [[4yq3|4yq3]], [[4yq4|4yq4]], [[4yq5|4yq5]], [[4yq6|4yq6]], [[4yq7|4yq7]], [[4yq8|4yq8]], [[4yq9|4yq9]], [[4yqa|4yqa]], [[4yqb|4yqb]], [[4yqc|4yqc]], [[4yqg|4yqg]], [[4yqi|4yqi]], [[4yqj|4yqj]], [[4yqk|4yqk]], [[4yql|4yql]], [[4yqn|4yqn]], [[4yqo|4yqo]], [[4yqp|4yqp]], [[4yqq|4yqq]], [[4yqr|4yqr]], [[4yqs|4yqs]], [[4yqt|4yqt]], [[4ypy|4ypy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqd OCA], [https://pdbe.org/4yqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yqd RCSB], [https://www.ebi.ac.uk/pdbsum/4yqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqd ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">trmD, HI_0202 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqd OCA], [http://pdbe.org/4yqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqd RCSB], [http://www.ebi.ac.uk/pdbsum/4yqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
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[https://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
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==See Also==
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*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Haein]]
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[[Category: Haemophilus influenzae Rd KW20]]
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[[Category: Bonnette, W G]]
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[[Category: Large Structures]]
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[[Category: Elkins, P A]]
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[[Category: Bonnette WG]]
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[[Category: Madauss, K P]]
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[[Category: Elkins PA]]
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[[Category: Knot]]
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[[Category: Madauss KP]]
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[[Category: Sam-binding]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trmd]]
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Revision as of 08:25, 3 May 2023

Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds

PDB ID 4yqd

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