5d9r

From Proteopedia

(Difference between revisions)

Revision as of 10:27, 21 June 2023

Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6

Structural highlights

5d9r is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ARC6_ARATH Component of the plastid division machinery. Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1. Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring. Required for plastid equatorial positioning of PDV2 and ARC5. May contribute to gravitropism in stems and hypocotyls. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8]

Publication Abstract from PubMed

The chloroplast division machinery is composed of numerous proteins that assemble as a large complex to divide double-membraned chloroplasts through binary fission. A key mediator of division-complex formation is ARC6, a chloroplast inner envelope protein and evolutionary descendant of the cyanobacterial cell division protein Ftn2. ARC6 connects stromal and cytosolic contractile rings across the two membranes through interaction with an outer envelope protein within the intermembrane space (IMS). The ARC6 IMS region bears a structurally uncharacterized domain of unknown function, DUF4101, that is highly conserved among ARC6 and Ftn2 proteins. Here we report the crystal structure of this domain from Arabidopsis thaliana ARC6. The domain forms an alpha/beta barrel open towards the outer envelope membrane but closed towards the inner envelope membrane. These findings provide new clues into how ARC6 and its homologs contribute to chloroplast and cyanobacterial cell division.

Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.,Kumar N, Radhakrishnan A, Su CC, Osteryoung KW, Yu EW Protein Sci. 2016 Feb;25(2):523-9. doi: 10.1002/pro.2825. Epub 2015 Oct 29. PMID:26452626^[9]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Marrison JL, Rutherford SM, Robertson EJ, Lister C, Dean C, Leech RM. The distinctive roles of five different ARC genes in the chloroplast division process in Arabidopsis. Plant J. 1999 Jun;18(6):651-62. PMID:10417716
↑ Yamamoto K, Pyke KA, Kiss JZ. Reduced gravitropism in inflorescence stems and hypocotyls, but not roots, of Arabidopsis mutants with large plastids. Physiol Plant. 2002 Apr;114(4):627-636. PMID:11975738
↑ Pyke KA, Rutherford SM, Robertson EJ, Leech RM. arc6, A Fertile Arabidopsis Mutant with Only Two Mesophyll Cell Chloroplasts. Plant Physiol. 1994 Nov;106(3):1169-1177. PMID:12232400
↑ Vitha S, Froehlich JE, Koksharova O, Pyke KA, van Erp H, Osteryoung KW. ARC6 is a J-domain plastid division protein and an evolutionary descendant of the cyanobacterial cell division protein Ftn2. Plant Cell. 2003 Aug;15(8):1918-33. PMID:12897262
↑ Holzinger A, Kwok EY, Hanson MR. Effects of arc3, arc5 and arc6 mutations on plastid morphology and stromule formation in green and nongreen tissues of Arabidopsis thaliana. Photochem Photobiol. 2008 Nov-Dec;84(6):1324-35. doi:, 10.1111/j.1751-1097.2008.00437.x. Epub 2008 Aug 29. PMID:18764889 doi:http://dx.doi.org/10.1111/j.1751-1097.2008.00437.x
↑ Glynn JM, Froehlich JE, Osteryoung KW. Arabidopsis ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space. Plant Cell. 2008 Sep;20(9):2460-70. doi: 10.1105/tpc.108.061440. Epub 2008 Sep, 23. PMID:18812496 doi:http://dx.doi.org/10.1105/tpc.108.061440
↑ Robertson EJ, Pyke KA, Leech RM. arc6, an extreme chloroplast division mutant of Arabidopsis also alters proplastid proliferation and morphology in shoot and root apices. J Cell Sci. 1995 Sep;108 ( Pt 9):2937-44. PMID:8537433
↑ Pyke KA, Page AM. Plastid ontogeny during petal development in Arabidopsis. Plant Physiol. 1998 Feb;116(2):797-803. PMID:9489024
↑ Kumar N, Radhakrishnan A, Su CC, Osteryoung KW, Yu EW. Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6. Protein Sci. 2016 Feb;25(2):523-9. doi: 10.1002/pro.2825. Epub 2015 Oct 29. PMID:26452626 doi:http://dx.doi.org/10.1002/pro.2825

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5d9r"

@@ Line 1: / Line 1: @@
 ==Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6==
-<StructureSection load='5d9r' size='340' side='right' caption='[[5d9r]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
+<StructureSection load='5d9r' size='340' side='right'caption='[[5d9r]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5d9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D9R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5d9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D9R FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARC6, At5g42480, MDH9.18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9r OCA], [https://pdbe.org/5d9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d9r RCSB], [https://www.ebi.ac.uk/pdbsum/5d9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9r ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9r OCA], [http://pdbe.org/5d9r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d9r RCSB], [http://www.ebi.ac.uk/pdbsum/5d9r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9r ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ARC6_ARATH ARC6_ARATH]] Component of the plastid division machinery. Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1. Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring. Required for plastid equatorial positioning of PDV2 and ARC5. May contribute to gravitropism in stems and hypocotyls. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency.<ref>PMID:10417716</ref> <ref>PMID:11975738</ref> <ref>PMID:12232400</ref> <ref>PMID:12897262</ref> <ref>PMID:18764889</ref> <ref>PMID:18812496</ref> <ref>PMID:8537433</ref> <ref>PMID:9489024</ref>
+[https://www.uniprot.org/uniprot/ARC6_ARATH ARC6_ARATH] Component of the plastid division machinery. Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1. Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring. Required for plastid equatorial positioning of PDV2 and ARC5. May contribute to gravitropism in stems and hypocotyls. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency.<ref>PMID:10417716</ref> <ref>PMID:11975738</ref> <ref>PMID:12232400</ref> <ref>PMID:12897262</ref> <ref>PMID:18764889</ref> <ref>PMID:18812496</ref> <ref>PMID:8537433</ref> <ref>PMID:9489024</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Arath]]
+[[Category: Arabidopsis thaliana]]
-[[Category: Chou, T H]]
+[[Category: Large Structures]]
-[[Category: Kumar, N]]
+[[Category: Chou T-H]]
-[[Category: Radhakrishnan, A]]
+[[Category: Kumar N]]
-[[Category: Su, C C]]
+[[Category: Radhakrishnan A]]
-[[Category: Yu, E]]
+[[Category: Su C-C]]
-[[Category: Biosynthetic protein]]
+[[Category: Yu E]]
-[[Category: Plastid division machinery]]

5d9r

From Proteopedia

Revision as of 10:27, 21 June 2023

Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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