2b6p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2b6p.gif|left|200px]]
[[Image:2b6p.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2b6p |SIZE=350|CAPTION= <scene name='initialview01'>2b6p</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_2b6p", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2b6p| PDB=2b6p | SCENE= }}
-
|RELATEDENTRY=[[1sor|1SOR]], [[2b6o|2B6O]], [[1ymg|1YMG]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b6p OCA], [http://www.ebi.ac.uk/pdbsum/2b6p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b6p RCSB]</span>
+
-
}}
+
'''X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state'''
'''X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state'''
Line 32: Line 29:
[[Category: Sliz, P.]]
[[Category: Sliz, P.]]
[[Category: Walz, T.]]
[[Category: Walz, T.]]
-
[[Category: aqp0]]
+
[[Category: Aqp0]]
-
[[Category: aquaporin]]
+
[[Category: Aquaporin]]
-
[[Category: aquaporin-0]]
+
[[Category: Aquaporin-0]]
-
[[Category: lens mip]]
+
[[Category: Lens mip]]
-
[[Category: membrane protein;]]
+
[[Category: Membrane protein;]]
-
[[Category: open water pore]]
+
[[Category: Open water pore]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:55:31 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:02:15 2008''
+

Revision as of 16:55, 3 May 2008

Image:2b6p.gif

Template:STRUCTURE 2b6p

X-ray structure of lens Aquaporin-0 (AQP0) (lens MIP) in an open pore state


Overview

Lens-specific aquaporin-0 (AQP0) functions as a specific water pore and forms the thin junctions between fibre cells. Here we describe a 1.9 A resolution structure of junctional AQP0, determined by electron crystallography of double-layered two-dimensional crystals. Comparison of junctional and non-junctional AQP0 structures shows that junction formation depends on a conformational switch in an extracellular loop, which may result from cleavage of the cytoplasmic amino and carboxy termini. In the centre of the water pathway, the closed pore in junctional AQP0 retains only three water molecules, which are too widely spaced to form hydrogen bonds with each other. Packing interactions between AQP0 tetramers in the crystalline array are mediated by lipid molecules, which assume preferred conformations. We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions.

About this Structure

2B6P is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals., Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T, Nature. 2005 Dec 1;438(7068):633-8. PMID:16319884 Page seeded by OCA on Sat May 3 19:55:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b6p"
Personal tools