2b9i

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[[Image:2b9i.gif|left|200px]]
[[Image:2b9i.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2b9i |SIZE=350|CAPTION= <scene name='initialview01'>2b9i</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2b9i", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FUS3, DAC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_2b9i| PDB=2b9i | SCENE= }}
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|RELATEDENTRY=[[2b9f|2B9F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9i OCA], [http://www.ebi.ac.uk/pdbsum/2b9i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b9i RCSB]</span>
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}}
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'''Crystal structure of Fus3 with a docking motif from Msg5'''
'''Crystal structure of Fus3 with a docking motif from Msg5'''
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[[Category: Lim, W A.]]
[[Category: Lim, W A.]]
[[Category: Remenyi, A.]]
[[Category: Remenyi, A.]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:01:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:03:14 2008''
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Revision as of 17:01, 3 May 2008

Image:2b9i.gif

Template:STRUCTURE 2b9i

Crystal structure of Fus3 with a docking motif from Msg5


Overview

Cells use a network of mitogen-activated protein kinases (MAPKs) to coordinate responses to diverse extracellular signals. Here, we examine the role of docking interactions in determining connectivity of the yeast MAPKs Fus3 and Kss1. These closely related kinases are activated by the common upstream MAPK kinase Ste7 yet generate distinct output responses, mating and filamentous growth, respectively. We find that docking interactions are necessary for communication with the kinases and that they can encode subtle differences in pathway-specific input and output. The cell cycle arrest mediator Far1, a mating-specific substrate, has a docking motif that selectively binds Fus3. In contrast, the shared partner Ste7 has a promiscuous motif that binds both Fus3 and Kss1. Structural analysis reveals that Fus3 interacts with specific and promiscuous peptides in conformationally distinct modes. Induced fit recognition may allow docking peptides to achieve discrimination by exploiting subtle differences in kinase flexibility.

About this Structure

2B9I is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network., Remenyi A, Good MC, Bhattacharyya RP, Lim WA, Mol Cell. 2005 Dec 22;20(6):951-62. PMID:16364919 Page seeded by OCA on Sat May 3 20:01:05 2008

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