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4zgz

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==STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME==
==STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME==
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<StructureSection load='4zgz' size='340' side='right' caption='[[4zgz]], [[Resolution|resolution]] 5.81&Aring;' scene=''>
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<StructureSection load='4zgz' size='340' side='right'caption='[[4zgz]], [[Resolution|resolution]] 5.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zgz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zgz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZGZ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qcg|4qcg]], [[3btn|3btn]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgz OCA], [https://pdbe.org/4zgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zgz RCSB], [https://www.ebi.ac.uk/pdbsum/4zgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgz ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AZIN1, OAZI, OAZIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), OAZ1, OAZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgz OCA], [http://pdbe.org/4zgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgz RCSB], [http://www.ebi.ac.uk/pdbsum/4zgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AZIN1_HUMAN AZIN1_HUMAN]] Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.<ref>PMID:17900240</ref> [[http://www.uniprot.org/uniprot/OAZ1_HUMAN OAZ1_HUMAN]] Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.<ref>PMID:12097147</ref> <ref>PMID:17900240</ref>
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[https://www.uniprot.org/uniprot/AZIN1_HUMAN AZIN1_HUMAN] Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.<ref>PMID:17900240</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zgz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zgz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antizyme inhibitor 3D structures|Antizyme inhibitor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chan, N L]]
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[[Category: Large Structures]]
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[[Category: Chen, S F]]
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[[Category: Chan NL]]
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[[Category: Wu, H Y]]
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[[Category: Chen SF]]
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[[Category: Antizyme]]
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[[Category: Wu HY]]
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[[Category: Beta-sheet domain]]
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[[Category: Inhibition]]
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[[Category: Plasma]]
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[[Category: Protein binding]]
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[[Category: Tim barrel domain]]
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Revision as of 07:27, 18 May 2023

STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME

PDB ID 4zgz

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