Cryptochrome
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='4i6g' size='340' side='right' caption='Mouse cryptochrome-1 complex with FAD (PDB code 4i6g)' scene=''> == Function == Cryptochrome (Cry) is a flavoprotein ...) |
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<StructureSection load='4i6g' size='340' side='right' caption='Mouse cryptochrome-1 complex with FAD (PDB code [[4i6g]])' scene=''> | <StructureSection load='4i6g' size='340' side='right' caption='Mouse cryptochrome-1 complex with FAD (PDB code [[4i6g]])' scene=''> | ||
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The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>. | The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>. | ||
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| - | == Relevance == | ||
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| - | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 11:34, 20 November 2017
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3D Structures of cryptochrome
Updated on 20-November-2017
4i6e, 4k0r, 5t5x – mCry-1 – mouse
4jzy, 4gu5, 4k03 – Cry-1 + FAD – Drosophila melanogaster
1u3c – AtCry-1 PHR domain + FAD - Arabidopsis thaliana
1u3d – AtCry-1 PHR domain + FAD + AMPPNP
4ct0 – mCry-1 + PER2
4i6g – mCry-2 + FAD
4u8h – mCry-2 + PER2
4mlp – mCry-2 + carbazol derivative
3zxs – Cry-2 + FAD – Rhodobacter sphaeroides
2j4d, 2ijg – AtCry-3 + FAD
2vtb – AtCry-3 + FAD + DNA
3fy4 – AtCry 6-4 + FAD
1np7 – Cry - Synechocystis
References
- ↑ Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702
- ↑ Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109
