5y7x
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist== | |
| - | + | <StructureSection load='5y7x' size='340' side='right' caption='[[5y7x]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5y7x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y7X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8RR:2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-selenazol-5-yl]methylsulfanyl]phenoxy]ethanoic+acid'>8RR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7x OCA], [http://pdbe.org/5y7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y7x RCSB], [http://www.ebi.ac.uk/pdbsum/5y7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7x ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Yoon, H | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Bae, J H]] | ||
| + | [[Category: Chin, J W]] | ||
| + | [[Category: Cho, S J]] | ||
| + | [[Category: Kim, H L]] | ||
| + | [[Category: Song, J Y]] | ||
| + | [[Category: Yoon, H S]] | ||
| + | [[Category: Diabetes]] | ||
| + | [[Category: Peroxisome proliferator-activated receptor]] | ||
| + | [[Category: Pi-sulfur interaction]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Selenazole]] | ||
Revision as of 18:38, 1 August 2018
Human Peroxisome proliferator-activated receptor (PPAR) delta in complexed with a potent and selective agonist
| |||||||||||
