5yf2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of CARNMT1 bound to anserine and SAH== | |
| - | + | <StructureSection load='5yf2' size='340' side='right' caption='[[5yf2]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yf2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YF2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8V3:(2~{S})-2-(3-azanylpropanoylamino)-3-(3-methylimidazol-4-yl)propanoic+acid'>8V3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnosine_N-methyltransferase Carnosine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.22 2.1.1.22] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yf2 OCA], [http://pdbe.org/5yf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yf2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CARME_HUMAN CARME_HUMAN]] N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).<ref>PMID:26001783</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Carnosine N-methyltransferase]] | ||
| + | [[Category: Cao, R]] | ||
[[Category: Li, H]] | [[Category: Li, H]] | ||
| - | [[Category: | + | [[Category: Methyltransferase]] |
| + | [[Category: Sam]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 18:39, 1 August 2018
Crystal structure of CARNMT1 bound to anserine and SAH
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