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6b99
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Hsp90-alpha N-domain bound to NECA== | |
| - | + | <StructureSection load='6b99' size='340' side='right' caption='[[6b99]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b99]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B99 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEC:N-ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b99 OCA], [http://pdbe.org/6b99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b99 RCSB], [http://www.ebi.ac.uk/pdbsum/6b99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b99 ProSAT]</span></td></tr> |
| - | [[Category: Huck, J | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gewirth, D T]] | ||
| + | [[Category: Huck, J D]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Chaperone-inhibitor complex]] | ||
| + | [[Category: Hsp90]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 07:53, 17 October 2018
Hsp90-alpha N-domain bound to NECA
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