6bka
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Nitronate Monooxygenase from Cyberlindnera saturnus== | |
| + | <StructureSection load='6bka' size='340' side='right' caption='[[6bka]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bka]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BKA FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33O:3,6,9,12,15,18,21,24,27,30,33,36-DODECAOXAOCTATRIACONTANE-1,38-DIOL'>33O</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitronate_monooxygenase Nitronate monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.16 1.13.12.16] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bka OCA], [http://pdbe.org/6bka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bka RCSB], [http://www.ebi.ac.uk/pdbsum/6bka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bka ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/2NPD_CYBMR 2NPD_CYBMR]] Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Nitronate monooxygenase (NMO) is an FMN-dependent enzyme that oxidizes the neurotoxin propionate 3-nitronate (P3N) and represents the best-known system for P3N detoxification in different organisms. The crystal structure of the first eukaryotic Class I NMO from Cyberlindnera saturnus (CsNMO) has been solved at 1.65 A resolution and refined to an R-factor of 14.0%. The three-dimensional structures of yeast CsNMO and bacterial PaNMO are highly conserved with the exception of three additional loops on the surface in the CsNMO enzyme and differences in four active sites residues. A PEG molecule was identified in the structure and formed extensive interactions with CsNMO, suggesting a specific binding site; however, 8% PEG showed no significant effect on the enzyme activity. This new crystal structure of a eukaryotic NMO provides insight into the function of this class of enzymes. | ||
| - | + | Crystal structure of yeast nitronate monooxygenase from Cyberlindnera saturnus.,Agniswamy J, Reis RAG, Wang YF, Smitherman C, Su D, Weber I, Gadda G Proteins. 2018 Jan 31. doi: 10.1002/prot.25470. PMID:29383742<ref>PMID:29383742</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6bka" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Nitronate monooxygenase]] | ||
[[Category: Agniswamy, J]] | [[Category: Agniswamy, J]] | ||
| - | [[Category: Fang, Y | + | [[Category: Fang, Y F]] |
| - | [[Category: Weber, I | + | [[Category: Weber, I T]] |
| + | [[Category: Monooxygenase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Propionate 3-nitronate]] | ||
Revision as of 06:33, 15 February 2018
Crystal Structure of Nitronate Monooxygenase from Cyberlindnera saturnus
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