2bbd
From Proteopedia
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'''Crystal Structure of the STIV MCP''' | '''Crystal Structure of the STIV MCP''' | ||
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[[Category: Sulfolobus turreted icosahedral virus]] | [[Category: Sulfolobus turreted icosahedral virus]] | ||
[[Category: Khayat, R.]] | [[Category: Khayat, R.]] | ||
| - | [[Category: | + | [[Category: Archaea]] |
| - | [[Category: | + | [[Category: Crystal]] |
| - | [[Category: | + | [[Category: Evolution]] |
| - | [[Category: | + | [[Category: Hyperthermophile]] |
| - | [[Category: | + | [[Category: Virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:04:12 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:04, 3 May 2008
Crystal Structure of the STIV MCP
Overview
Archaea and their viruses are poorly understood when compared with the Eukarya and Bacteria domains of life. We report here the crystal structure of the major capsid protein (MCP) of the Sulfolobus turreted icosahedral virus, an archaeal virus isolated from an acidic hot spring (pH 2-4, 72-92 degrees C) in Yellowstone National Park. The structure is nearly identical to the MCP structures of the eukaryotic Paramecium bursaria Chlorella virus, and the bacteriophage PRD1, and shows a common fold with the mammalian adenovirus. Structural analysis of the capsid architecture, determined by fitting the subunit into the electron cryomicroscopy reconstruction of the virus, identified a number of key interactions that are akin to those observed in adenovirus and PRD1. The similar capsid proteins and capsid architectures strongly suggest that these viral capsids originated and evolved from a common ancestor. Hence, this work provides a previously undescribed example of a viral relationship spanning the three domains of life (Eukarya, Bacteria, and Archaea). The MCP structure also provides insights into the stabilizing forces required for extracellular hyperthermophilic proteins to tolerate high-temperature hot springs.
About this Structure
2BBD is a Single protein structure of sequence from Sulfolobus turreted icosahedral virus. Full crystallographic information is available from OCA.
Reference
Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses., Khayat R, Tang L, Larson ET, Lawrence CM, Young M, Johnson JE, Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18944-9. Epub 2005 Dec 15. PMID:16357204 Page seeded by OCA on Sat May 3 20:04:12 2008
