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6ey7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound== | |
| - | + | <StructureSection load='6ey7' size='340' side='right' caption='[[6ey7]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ey7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EY7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EY7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C3W:4-[(4-fluorophenyl)methyl-methyl-amino]-2,4-bis(oxidanylidene)butanoic+acid'>C3W</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ey7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ey7 OCA], [http://pdbe.org/6ey7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ey7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ey7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ey7 ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TRM3_HCMVA TRM3_HCMVA]] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Albericio, F]] | [[Category: Albericio, F]] | ||
[[Category: Alvarez, M]] | [[Category: Alvarez, M]] | ||
| + | [[Category: Bongarzone, S]] | ||
| + | [[Category: Coll, M]] | ||
| + | [[Category: Kaczmarska, Z]] | ||
[[Category: Machon, M]] | [[Category: Machon, M]] | ||
[[Category: Nadal, M]] | [[Category: Nadal, M]] | ||
| - | [[Category: | + | [[Category: Cytomegalovirus]] |
| + | [[Category: Drug design]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Raltegravir]] | ||
| + | [[Category: Terminase]] | ||
| + | [[Category: Ul89]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 07:50, 3 October 2018
Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound
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Categories: Albericio, F | Alvarez, M | Bongarzone, S | Coll, M | Kaczmarska, Z | Machon, M | Nadal, M | Cytomegalovirus | Drug design | Inhibitor | Raltegravir | Terminase | Ul89 | Viral protein
