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2bdy

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[[Image:2bdy.jpg|left|200px]]
[[Image:2bdy.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2bdy |SIZE=350|CAPTION= <scene name='initialview01'>2bdy</scene>, resolution 1.610&Aring;
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The line below this paragraph, containing "STRUCTURE_2bdy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TYS:SULFONATED+TYROSINE'>TYS</scene>, <scene name='pdbligand=UNB:N-(4-CARBAMIMIDOYL-BENZYL)-2-[2-HYDROXY-6-METHYL-3-(NAPHTHALENE-1-SULFONYLAMINO)-PHENYL]-ACETAMIDE'>UNB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bdy| PDB=2bdy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdy OCA], [http://www.ebi.ac.uk/pdbsum/2bdy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bdy RCSB]</span>
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}}
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'''thrombin in complex with inhibitor'''
'''thrombin in complex with inhibitor'''
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[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
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[[Category: complex structure]]
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[[Category: Complex structure]]
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[[Category: thrombin]]
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[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:09:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:04:56 2008''
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Revision as of 17:09, 3 May 2008

Image:2bdy.jpg

Template:STRUCTURE 2bdy

thrombin in complex with inhibitor


Overview

Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.

About this Structure

2BDY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure., Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellstrom O, Xue Y, Bioorg Med Chem Lett. 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15. PMID:16290930 Page seeded by OCA on Sat May 3 20:09:34 2008

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OCA

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