This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3whw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==MTH1 in complex with Ruthenium-based inhibitor==
==MTH1 in complex with Ruthenium-based inhibitor==
-
<StructureSection load='3whw' size='340' side='right' caption='[[3whw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='3whw' size='340' side='right'caption='[[3whw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3whw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WHW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3whw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WHW FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RUX:[4-AMINO-2-METHYL-6-(PYRIDIN-2-YL-KAPPAN)QUINAZOLIN-7-YL-KAPPAC~7~](CARBONYL){1-[(2,6-DIMETHOXYPHENOXY)CARBONYL]CYCLOPENTA-2,4-DIEN-1-YL}RUTHENIUM'>RUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RUX:[4-AMINO-2-METHYL-6-(PYRIDIN-2-YL-KAPPAN)QUINAZOLIN-7-YL-KAPPAC~7~](CARBONYL){1-[(2,6-DIMETHOXYPHENOXY)CARBONYL]CYCLOPENTA-2,4-DIEN-1-YL}RUTHENIUM'>RUX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zr1|3zr1]]</td></tr>
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zr1|3zr1]]</div></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT1, MTH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3whw OCA], [http://pdbe.org/3whw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3whw RCSB], [http://www.ebi.ac.uk/pdbsum/3whw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3whw ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3whw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3whw OCA], [https://pdbe.org/3whw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3whw RCSB], [https://www.ebi.ac.uk/pdbsum/3whw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3whw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+
[[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 20:
</div>
</div>
<div class="pdbe-citations 3whw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3whw" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 25: Line 28:
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
 +
[[Category: Large Structures]]
[[Category: Kraeling, K]]
[[Category: Kraeling, K]]
[[Category: Meggers, E]]
[[Category: Meggers, E]]

Revision as of 05:37, 3 August 2022

MTH1 in complex with Ruthenium-based inhibitor

PDB ID 3whw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3whw"
Personal tools