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4nhm

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==Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)==
==Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)==
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<StructureSection load='4nhm' size='340' side='right' caption='[[4nhm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4nhm' size='340' side='right'caption='[[4nhm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nhm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NHM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nhm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NHM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UN9:N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE'>UN9</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UN9:N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE'>UN9</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nhl|4nhl]], [[4nhk|4nhk]], [[4nhx|4nhx]], [[4nhy|4nhy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nhm OCA], [https://pdbe.org/4nhm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nhm RCSB], [https://www.ebi.ac.uk/pdbsum/4nhm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nhm ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPA1, YER049W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nhm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nhm OCA], [http://pdbe.org/4nhm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nhm RCSB], [http://www.ebi.ac.uk/pdbsum/4nhm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nhm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TPA1_YEAST TPA1_YEAST]] Part of a messenger ribonucleoprotein (mRNP) complex at the 3'-UTR of mRNAs. It associates specifically with components of the translation termination complex and is involved in both translation termination and in regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.<ref>PMID:16809762</ref>
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[https://www.uniprot.org/uniprot/TPA1_YEAST TPA1_YEAST] Part of a messenger ribonucleoprotein (mRNP) complex at the 3'-UTR of mRNAs. It associates specifically with components of the translation termination complex and is involved in both translation termination and in regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.<ref>PMID:16809762</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
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[[Category: McDonough, M A]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Schofield, C J]]
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[[Category: McDonough MA]]
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[[Category: Scotti, J S]]
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[[Category: Schofield CJ]]
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[[Category: 2-oxoglutarate oxygenase]]
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[[Category: Scotti JS]]
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[[Category: Double-stranded beta helix]]
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[[Category: Jellyroll fold]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Oxygen sensing]]
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[[Category: Prolyl hydroxylase]]
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[[Category: Protein synthesis regulation]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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Revision as of 08:29, 11 January 2023

Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

PDB ID 4nhm

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