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4pfd
From Proteopedia
(Difference between revisions)
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==Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct== | ==Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct== | ||
| - | <StructureSection load='4pfd' size='340' side='right' caption='[[4pfd]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='4pfd' size='340' side='right'caption='[[4pfd]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4pfd]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4pfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFD FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2R2:[4-(2-METHOXYETHYL)PIPERAZIN-1-YL][6-METHYL-7-NITRO-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]METHANONE'>2R2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2R2:[4-(2-METHOXYETHYL)PIPERAZIN-1-YL][6-METHYL-7-NITRO-5-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-YL]METHANONE'>2R2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfd OCA], [https://pdbe.org/4pfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfd RCSB], [https://www.ebi.ac.uk/pdbsum/4pfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfd ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: | + | [[Category: Cole S]] |
| - | [[Category: | + | [[Category: Neres J]] |
| - | [[Category: | + | [[Category: Panda M]] |
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 12:59, 1 February 2023
Crystal structure of M. tuberculosis in complex with a cBT - non-covalent adduct
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