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4r9w

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Current revision (06:46, 2 March 2023) (edit) (undo)
 
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==Crystal structure of platelet factor 4 complexed with fondaparinux==
==Crystal structure of platelet factor 4 complexed with fondaparinux==
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<StructureSection load='4r9w' size='340' side='right' caption='[[4r9w]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4r9w' size='340' side='right'caption='[[4r9w]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r9w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R9W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r9w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R9W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NTO:TRISULFOAMINO+HEPARIN+PENTASACCHARIDE'>NTO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=PRD_900028:fondaparinux'>PRD_900028</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SUS:2-DEOXY-3,6-DI-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSE'>SUS</scene>, <scene name='pdbligand=ZDO:methyl+2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside'>ZDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r97|4r97]], [[4r9y|4r9y]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r9w OCA], [https://pdbe.org/4r9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r9w RCSB], [https://www.ebi.ac.uk/pdbsum/4r9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r9w ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF4, CXCL4, SCYB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r9w OCA], [http://pdbe.org/4r9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r9w RCSB], [http://www.ebi.ac.uk/pdbsum/4r9w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r9w ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PLF4_HUMAN PLF4_HUMAN]] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<ref>PMID:7644496</ref>
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[https://www.uniprot.org/uniprot/PLF4_HUMAN PLF4_HUMAN] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<ref>PMID:7644496</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4r9w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4r9w" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cai, Z]]
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[[Category: Large Structures]]
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[[Category: Greene, M I]]
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[[Category: Cai Z]]
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[[Category: Liu, Q]]
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[[Category: Greene MI]]
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[[Category: Zhu, Z]]
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[[Category: Liu Q]]
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[[Category: Cxc chemokine]]
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[[Category: Zhu Z]]
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[[Category: Cytokine]]
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[[Category: Fondaparinux]]
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[[Category: Glycosaminoglycan]]
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[[Category: Pf4]]
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[[Category: Platelet]]
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[[Category: Platelet factor]]
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Current revision

Crystal structure of platelet factor 4 complexed with fondaparinux

PDB ID 4r9w

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