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4x0t

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==Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+==
==Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+==
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<StructureSection load='4x0t' size='340' side='right' caption='[[4x0t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4x0t' size='340' side='right'caption='[[4x0t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x0t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X0T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X0T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3W9:4-(DIETHYLAMINO)BENZALDEHYDE'>3W9</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3W9:4-(DIETHYLAMINO)BENZALDEHYDE'>3W9</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x0u|4x0u]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x0t OCA], [https://pdbe.org/4x0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x0t RCSB], [https://www.ebi.ac.uk/pdbsum/4x0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x0t ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH7A1, ATQ1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x0t OCA], [http://pdbe.org/4x0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x0t RCSB], [http://www.ebi.ac.uk/pdbsum/4x0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x0t ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN]] Pyridoxine-dependent epilepsy. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN] Pyridoxine-dependent epilepsy. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN]] Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.<ref>PMID:16491085</ref> <ref>PMID:20207735</ref>
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[https://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN] Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.<ref>PMID:16491085</ref> <ref>PMID:20207735</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4x0t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4x0t" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Luo, M]]
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[[Category: Large Structures]]
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[[Category: Tanner, J J]]
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[[Category: Luo M]]
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[[Category: Aldehyde dehydrogenase]]
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[[Category: Tanner JJ]]
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[[Category: Lysine catabolism]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Revision as of 21:06, 12 April 2023

Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+

PDB ID 4x0t

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