2bip

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[[Image:2bip.gif|left|200px]]
[[Image:2bip.gif|left|200px]]
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{{Structure
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|PDB= 2bip |SIZE=350|CAPTION= <scene name='initialview01'>2bip</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2bip", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_2bip| PDB=2bip | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bip OCA], [http://www.ebi.ac.uk/pdbsum/2bip PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bip RCSB]</span>
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}}
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'''HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-R249S-N268D'''
'''HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-R249S-N268D'''
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[[Category: Joerger, A C.]]
[[Category: Joerger, A C.]]
[[Category: 3d-structure]]
[[Category: 3d-structure]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: anti-oncogene]]
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[[Category: Anti-oncogene]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: dna-binding protein]]
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[[Category: Dna-binding protein]]
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[[Category: glycoprotein metal-binding]]
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[[Category: Glycoprotein metal-binding]]
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[[Category: li-fraumeni syndrome]]
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[[Category: Li-fraumeni syndrome]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: p53 dna-binding domain]]
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[[Category: P53 dna-binding domain]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: second-site suppressor mutation]]
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[[Category: Second-site suppressor mutation]]
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[[Category: superstable mutant]]
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[[Category: Superstable mutant]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: tumor suppressor]]
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[[Category: Tumor suppressor]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:20:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:03 2008''
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Revision as of 17:20, 3 May 2008

Image:2bip.gif

Template:STRUCTURE 2bip

HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-R249S-N268D


Overview

We have solved the crystal structures of three oncogenic mutants of the core domain of the human tumor suppressor p53. The mutations were introduced into a stabilized variant. The cancer hot spot mutation R273H simply removes an arginine involved in DNA binding without causing structural distortions in neighboring residues. In contrast, the "structural" oncogenic mutations H168R and R249S induce substantial structural perturbation around the mutation site in the L2 and L3 loops, respectively. H168R is a specific intragenic suppressor mutation for R249S. When both cancer mutations are combined in the same molecule, Arg(168) mimics the role of Arg(249) in wild type, and the wild type conformation is largely restored in both loops. Our structural and biophysical data provide compelling evidence for the mechanism of rescue of mutant p53 by intragenic suppressor mutations and reveal features by which proteins can adapt to deleterious mutations.

About this Structure

2BIP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations., Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR, J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 Page seeded by OCA on Sat May 3 20:20:40 2008

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OCA

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