4z3c
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3c OCA], [http://pdbe.org/4z3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3c RCSB], [http://www.ebi.ac.uk/pdbsum/4z3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z3c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3c OCA], [http://pdbe.org/4z3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3c RCSB], [http://www.ebi.ac.uk/pdbsum/4z3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z3c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities to CpG islands. Here we systematically measured and compared the DNA-binding selectivities of all known human CXXC domains by different binding assays, and complemented the existing function-based classification of human CXXC domains with a classification based on their DNA selectivities. Through a series of crystal structures of CXXC domains with DNA ligands, we unravel the molecular mechanisms of how these CXXC domains, including single CXXC domains and tandem CXXC-PHD domains, recognize distinct DNA ligands, which further supports our classification of human CXXC domains and also provides insights into selective recruitment of chromatin modifiers to their respective targets via CXXC domains recognizing different genomic DNA sequences. Our study facilitates the understanding of the relationship between the DNA-binding specificities of the CXXC proteins and their biological functions. | ||
| + | |||
| + | DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.,Xu C, Liu K, Lei M, Yang A, Li Y, Hughes TR, Min J Structure. 2017 Dec 16. pii: S0969-2126(17)30396-9. doi:, 10.1016/j.str.2017.11.022. PMID:29276034<ref>PMID:29276034</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4z3c" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
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[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
[[Category: Edwards, A M]] | [[Category: Edwards, A M]] | ||
[[Category: Liu, K]] | [[Category: Liu, K]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
[[Category: Xu, C]] | [[Category: Xu, C]] | ||
Revision as of 05:55, 3 January 2018
Zinc finger region of human TET3 in complex with CpG DNA
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Categories: Human | Arrowsmith, C H | Bountra, C | Dong, A | Edwards, A M | Liu, K | Min, J | Structural genomic | Tempel, W | Xu, C | Dna binding protein-dna complex | Dna-binding | Sgc | Zinc finger
