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5eak

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==Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties==
==Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties==
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<StructureSection load='5eak' size='340' side='right' caption='[[5eak]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5eak' size='340' side='right'caption='[[5eak]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EAK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EAK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=24R:N-[(1S,2R)-2-AMINOCYCLOHEXYL]-4-[6-(1-METHYL-1H-PYRAZOL-4-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]THIOPHENE-2-CARBOXAMIDE'>24R</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MARK2, EMK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=24R:N-[(1S,2R)-2-AMINOCYCLOHEXYL]-4-[6-(1-METHYL-1H-PYRAZOL-4-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]THIOPHENE-2-CARBOXAMIDE'>24R</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eak OCA], [http://pdbe.org/5eak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eak RCSB], [http://www.ebi.ac.uk/pdbsum/5eak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eak ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eak OCA], [https://pdbe.org/5eak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eak RCSB], [https://www.ebi.ac.uk/pdbsum/5eak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eak ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MARK2_HUMAN MARK2_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5eak" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5eak" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Su, H P]]
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[[Category: Large Structures]]
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[[Category: Catalytic domain]]
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[[Category: Su HP]]
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[[Category: Kinase inhibitor]]
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[[Category: Protein-serine-threonine kinase]]
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[[Category: Serine-threonine kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 06:19, 5 July 2023

Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties

PDB ID 5eak

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