2bjx
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2bjx.jpg|left|200px]] | [[Image:2bjx.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2bjx", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | | | + | --> |
| - | | | + | {{STRUCTURE_2bjx| PDB=2bjx | SCENE= }} |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''PROTEIN DISULFIDE ISOMERASE''' | '''PROTEIN DISULFIDE ISOMERASE''' | ||
| Line 33: | Line 30: | ||
[[Category: Penka, E.]] | [[Category: Penka, E.]] | ||
[[Category: Scheek, R M.]] | [[Category: Scheek, R M.]] | ||
| - | [[Category: | + | [[Category: Electron transport]] |
| - | [[Category: | + | [[Category: Endoplasmic reticulum]] |
| - | [[Category: | + | [[Category: Isomerase]] |
| - | [[Category: | + | [[Category: Redox-active center]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:23:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:23, 3 May 2008
PROTEIN DISULFIDE ISOMERASE
Overview
Protein disulfide isomerase (PDI) is a multifunctional protein of the endoplasmic reticulum, which catalyzes the formation, breakage and rearrangement of disulfide bonds during protein folding. It consists of four domains designated a, b, b and a. Both a and a domains contains an active site with the sequence motif -Cys-Gly-His-Cys-involved directly in thiol-disulfide exchange reactions. As expected these domains have structures very similar to the ubiquitous redox protein thioredoxin. A low-resolution NMR structure of the b domain revealed that this domain adopts a fold similar to the PDI a domain and thioredoxin [Kemmink, J., Darby, N.J., Dijkstra, K., Nilges, M. and Creighton, T.E. (1997) Curr. Biol. 7, 239-245]. A refined ensemble of solution structures based on the input of 1865 structural restraints shows that the structure of PDI b is well defined throughout the complete protein except for about 10 residues at the C-terminus of the sequence. 15N relaxation data show that these residues are disordered and not part of this structural domain. Therefore the domain boundaries of PDI can now be fixed with reasonable precision. Structural comparison of the PDI b domain with thioredoxin and PDI a reveals several features important for thiol-disulfide exchange activity.
About this Structure
2BJX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure in solution of the b domain of protein disulfide isomerase., Kemmink J, Dijkstra K, Mariani M, Scheek RM, Penka E, Nilges M, Darby NJ, J Biomol NMR. 1999 Apr;13(4):357-68. PMID:10383197 Page seeded by OCA on Sat May 3 20:23:24 2008
