5tmh
From Proteopedia
(Difference between revisions)
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==Structure of Zika virus NS5== | ==Structure of Zika virus NS5== | ||
| - | <StructureSection load='5tmh' size='340' side='right' caption='[[5tmh]], [[Resolution|resolution]] 3.28Å' scene=''> | + | <StructureSection load='5tmh' size='340' side='right'caption='[[5tmh]], [[Resolution|resolution]] 3.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5tmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TMH FirstGlance]. <br> | <table><tr><td colspan='2'>[[5tmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TMH FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tmh OCA], [http://pdbe.org/5tmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tmh RCSB], [http://www.ebi.ac.uk/pdbsum/5tmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tmh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tmh OCA], [http://pdbe.org/5tmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tmh RCSB], [http://www.ebi.ac.uk/pdbsum/5tmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tmh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The recent outbreak of Zika virus (ZIKV) has imposed a serious threat to public health. Here we report the crystal structure of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains stack into one of the two alternative conformations of flavivirus NS5 proteins. The activity of this NS5 protein is verified through a de novo RdRp assay on a subgenomic ZIKV RNA template. Importantly, our structural analysis leads to the identification of a potential drug-binding site of ZIKV NS5, which might facilitate the development of novel antivirals for ZIKV. | ||
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| + | The structure of Zika virus NS5 reveals a conserved domain conformation.,Wang B, Tan XF, Thurmond S, Zhang ZM, Lin A, Hai R, Song J Nat Commun. 2017 Mar 27;8:14763. doi: 10.1038/ncomms14763. PMID:28345600<ref>PMID:28345600</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5tmh" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Zikv]] | [[Category: Zikv]] | ||
[[Category: Song, J]] | [[Category: Song, J]] | ||
Revision as of 06:40, 31 July 2019
Structure of Zika virus NS5
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Categories: Large Structures | Zikv | Song, J | Tan, X | Wang, B | Viral protein
