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2bkt

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[[Image:2bkt.gif|left|200px]]
[[Image:2bkt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bkt |SIZE=350|CAPTION= <scene name='initialview01'>2bkt</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_2bkt", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Rpf+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=RPF:1-{4-[3-(2-METHOXY-BENZYLOXY)-PROPOXY]-PHENYL}-6-(1,2,,3,4-TETRAHYDRO-QUINOLIN-7-YLOXYMETHYL)-PIPERAZIN-2-ONE'>RPF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bkt| PDB=2bkt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bkt OCA], [http://www.ebi.ac.uk/pdbsum/2bkt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bkt RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX'''
'''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX'''
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[[Category: Ryan, J M.]]
[[Category: Ryan, J M.]]
[[Category: Zhang, E.]]
[[Category: Zhang, E.]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: renin]]
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[[Category: Renin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:25:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:57 2008''
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Revision as of 17:25, 3 May 2008

Image:2bkt.gif

Template:STRUCTURE 2bkt

CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX


Overview

We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.

About this Structure

2BKT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327 Page seeded by OCA on Sat May 3 20:25:37 2008

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