2bkt
From Proteopedia
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'''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX''' | '''CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX''' | ||
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[[Category: Ryan, J M.]] | [[Category: Ryan, J M.]] | ||
[[Category: Zhang, E.]] | [[Category: Zhang, E.]] | ||
- | [[Category: | + | [[Category: Aspartyl protease]] |
- | [[Category: | + | [[Category: Hydrolase]] |
- | [[Category: | + | [[Category: Renin]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:25:37 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 17:25, 3 May 2008
CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX
Overview
We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.
About this Structure
2BKT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327 Page seeded by OCA on Sat May 3 20:25:37 2008