2bm6
From Proteopedia
Line 1: | Line 1: | ||
[[Image:2bm6.gif|left|200px]] | [[Image:2bm6.gif|left|200px]] | ||
- | + | <!-- | |
- | + | The line below this paragraph, containing "STRUCTURE_2bm6", creates the "Structure Box" on the page. | |
- | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
- | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
- | | | + | or leave the SCENE parameter empty for the default display. |
- | + | --> | |
- | + | {{STRUCTURE_2bm6| PDB=2bm6 | SCENE= }} | |
- | + | ||
- | + | ||
- | }} | + | |
'''THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.''' | '''THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.''' | ||
Line 32: | Line 29: | ||
[[Category: Takiff, H E.]] | [[Category: Takiff, H E.]] | ||
[[Category: Vetting, M W.]] | [[Category: Vetting, M W.]] | ||
- | [[Category: | + | [[Category: Dna gyrase]] |
- | [[Category: | + | [[Category: Dna mimicry]] |
- | [[Category: | + | [[Category: Pentapeptide repeat protein,fluroquinolone resistance]] |
- | [[Category: | + | [[Category: Right-handed quadrilateral beta-helix]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:28:46 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 17:28, 3 May 2008
THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.
Overview
Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.
About this Structure
2BM6 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA., Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS, Science. 2005 Jun 3;308(5727):1480-3. PMID:15933203 Page seeded by OCA on Sat May 3 20:28:46 2008