2bme

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[[Image:2bme.gif|left|200px]]
[[Image:2bme.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bme |SIZE=350|CAPTION= <scene name='initialview01'>2bme</scene>, resolution 1.57&Aring;
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The line below this paragraph, containing "STRUCTURE_2bme", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bme| PDB=2bme | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bme OCA], [http://www.ebi.ac.uk/pdbsum/2bme PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bme RCSB]</span>
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}}
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'''HIGH RESOLUTION STRUCTURE OF GPPNHP-BOUND HUMAN RAB4A'''
'''HIGH RESOLUTION STRUCTURE OF GPPNHP-BOUND HUMAN RAB4A'''
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[[Category: Huber, S K.]]
[[Category: Huber, S K.]]
[[Category: Scheidig, A J.]]
[[Category: Scheidig, A J.]]
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[[Category: endocytosis]]
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[[Category: Endocytosis]]
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[[Category: gtp-binding protein]]
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[[Category: Gtp-binding protein]]
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[[Category: prenylation]]
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[[Category: Prenylation]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: transport]]
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[[Category: Transport]]
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[[Category: vesicular transport]]
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[[Category: Vesicular transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:29:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:08:33 2008''
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Revision as of 17:29, 3 May 2008

Image:2bme.gif

Template:STRUCTURE 2bme

HIGH RESOLUTION STRUCTURE OF GPPNHP-BOUND HUMAN RAB4A


Overview

The Ras-related human GTPase Rab4a is involved in the regulation of endocytosis through the sorting and recycling of early endosomes. Towards further insight, we have determined the three-dimensional crystal structure of human Rab4a in its GppNHp-bound state to 1.6 Angstroms resolution and in its GDP-bound state to 1.8 Angstroms resolution, respectively. Despite the similarity of the overall structure with other Rab proteins, Rab4a displays significant differences. The structures are discussed with respect to the recently determined structure of human Rab5a and its complex with the Rab5-binding domain of the bivalent effector Rabaptin-5. The Rab4 specific residue His39 modulates the nucleotide binding pocket giving rise to a reduced rate for nucleotide hydrolysis and exchange. In comparison to Rab5, Rab4a has a different GDP-bound conformation within switch 1 region and displays shifts in position and orientation of the hydrophobic triad. The observed differences at the S2-L3-S3 region represent a new example of structural plasticity among Rab proteins and may provide a structural basis to understand the differential binding of similar effector proteins.

About this Structure

2BME is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of human Rab4a in its active and inactive conformations., Huber SK, Scheidig AJ, FEBS Lett. 2005 May 23;579(13):2821-9. Epub 2005 Apr 25. PMID:15907487 Page seeded by OCA on Sat May 3 20:29:40 2008

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OCA

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