This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


UMP/CMP kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 7: Line 7:
== Relevance ==
== Relevance ==
-
everal cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
+
Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>.
</StructureSection>
</StructureSection>

Revision as of 20:34, 26 November 2017

Structure of human UMP/CMP kinase complex with sulfate (PDB entry 1tev)

Drag the structure with the mouse to rotate

3D Structures of UMP/CMP kinase

Updated on 26-November-2017

2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor
1tev – UCK – human

References

  1. ↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
  2. ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/UMP/CMP_kinase"
Personal tools