2boa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2boa.gif|left|200px]]
[[Image:2boa.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2boa |SIZE=350|CAPTION= <scene name='initialview01'>2boa</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_2boa", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+B'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2boa| PDB=2boa | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2boa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boa OCA], [http://www.ebi.ac.uk/pdbsum/2boa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2boa RCSB]</span>
+
-
}}
+
'''HUMAN PROCARBOXYPEPTIDASE A4.'''
'''HUMAN PROCARBOXYPEPTIDASE A4.'''
Line 32: Line 29:
[[Category: Vendrell, J.]]
[[Category: Vendrell, J.]]
[[Category: Ventura, S.]]
[[Category: Ventura, S.]]
-
[[Category: carboxypeptidase]]
+
[[Category: Carboxypeptidase]]
-
[[Category: exopropeptidase]]
+
[[Category: Exopropeptidase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: metalloprocarboxypeptidase]]
+
[[Category: Metalloprocarboxypeptidase]]
-
[[Category: metalloprotease]]
+
[[Category: Metalloprotease]]
-
[[Category: x-ray crystal structure]]
+
[[Category: X-ray crystal structure]]
-
[[Category: zymogen]]
+
[[Category: Zymogen]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:02 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:20 2008''
+

Revision as of 17:34, 3 May 2008

Image:2boa.gif

Template:STRUCTURE 2boa

HUMAN PROCARBOXYPEPTIDASE A4.


Overview

Treatment of advanced stages of prostate carcinoma with histone-deacetylase inhibitors entails expression of human procarboxypeptidase-A4 (hPCPA4). The three-dimensional structure of hPCPA4 has been solved and shows the features of related metallocarboxypeptidase zymogens, with a preformed alpha/beta/-hydrolase active-enzyme moiety (hCPA4) and an inhibiting pro-domain (PD). The protease moiety recalls a sphere, out of which a spherical cone has been cut. This results in a funnel-like structure, at the bottom of which the active-site cleft resides. The border of this funnel is shaped by loops, which are responsible for the interaction with the PD, characterised by a large interface area and relatively few contacts. Such an inhibitory mode is evocative of the recently reported structure of the human inhibitor latexin in its complex with hCPA4. The main contacting structure of latexin is similar to the one employed for PD inhibition. In both cases, active-site blocking relies mainly on a loop provided by the central part of a beta sheet.

About this Structure

2BOA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin., Garcia-Castellanos R, Bonet-Figueredo R, Pallares I, Ventura S, Aviles FX, Vendrell J, Gomis-Rutha FX, Cell Mol Life Sci. 2005 Sep;62(17):1996-2014. PMID:16091843 Page seeded by OCA on Sat May 3 20:34:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2boa"
Personal tools