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2boj

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[[Image:2boj.gif|left|200px]]
[[Image:2boj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2boj |SIZE=350|CAPTION= <scene name='initialview01'>2boj</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2boj", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ARW:METHYL+BETA-D-ARABINOPYRANOSIDE'>ARW</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2boj| PDB=2boj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2boj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2boj OCA], [http://www.ebi.ac.uk/pdbsum/2boj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2boj RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE'''
'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE'''
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[[Category: Sabin, C D.]]
[[Category: Sabin, C D.]]
[[Category: Wimmerova, M.]]
[[Category: Wimmerova, M.]]
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[[Category: lectin,arabinose,calcium,lewis a,cystic fibrosis]]
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[[Category: Lectin,arabinose,calcium,lewis a,cystic fibrosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:24 2008''
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Revision as of 17:34, 3 May 2008

Image:2boj.gif

Template:STRUCTURE 2boj

CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH METHYL-B-D-ARABINOPYRANOSIDE


Overview

The lectin from Pseudomonas aeruginosa (PA-IIL) is involved in host recognition and biofilm formation. Lectin not only displays an unusually high affinity for fucose but also binds to L-fucose, L-galactose and D-arabinose that differ only by the group at position 5 of the sugar ring. Isothermal calorimetry experiments provided precise determination of affinity for the three methyl-glycosides and revealed a large enthalpy contribution. The crystal structures of the complexes of PA-IIL with L-galactose and Met-beta-D-arabinoside have been determined and compared with the PA-IIL/fucose complex described previously. A combination of the structures and thermodynamics provided clues for the role of the hydrophobic group in affinity.

About this Structure

2BOJ is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures., Sabin C, Mitchell EP, Pokorna M, Gautier C, Utille JP, Wimmerova M, Imberty A, FEBS Lett. 2006 Feb 6;580(3):982-7. Epub 2006 Jan 19. PMID:16438968 Page seeded by OCA on Sat May 3 20:34:40 2008

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