2bob

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[[Image:2bob.gif|left|200px]]
[[Image:2bob.gif|left|200px]]
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{{Structure
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|PDB= 2bob |SIZE=350|CAPTION= <scene name='initialview01'>2bob</scene>, resolution 2.76&Aring;
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The line below this paragraph, containing "STRUCTURE_2bob", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=TBA:TETRABUTYLAMMONIUM+ION'>TBA</scene>, <scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene>
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{{STRUCTURE_2bob| PDB=2bob | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bob OCA], [http://www.ebi.ac.uk/pdbsum/2bob PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bob RCSB]</span>
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}}
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'''POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)'''
'''POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)'''
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[[Category: Lenaeus, M J.]]
[[Category: Lenaeus, M J.]]
[[Category: Vamvouka, M.]]
[[Category: Vamvouka, M.]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: ionic channel]]
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[[Category: Ionic channel]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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[[Category: protein-antibody fab complex]]
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[[Category: Protein-antibody fab complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:21 2008''
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Revision as of 17:34, 3 May 2008

Image:2bob.gif

Template:STRUCTURE 2bob

POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)


Overview

Potassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells, controlling heart rate and modulating the firing pattern in neurons. Tetraethylammonium (TEA) blocks ion conduction through potassium channels in a voltage-dependent manner from both sides of the membrane. Here we show the structural basis of TEA blockade by cocrystallizing the prokaryotic potassium channel KcsA with two selective TEA analogs. TEA binding at both sites alters ion occupancy in the selectivity filter; these findings underlie the mutual destabilization and voltage-dependence of TEA blockade. We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation.

About this Structure

2BOB is a Protein complex structure of sequences from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Structural basis of TEA blockade in a model potassium channel., Lenaeus MJ, Vamvouka M, Focia PJ, Gross A, Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24. PMID:15852022 Page seeded by OCA on Sat May 3 20:34:00 2008

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