This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6bp0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6bp0" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6bp0 is ON HOLD
+
==Crystal Structure of the Human vaccinia-related kinase 1 bound to pteridine inhibitor==
-
 
+
<StructureSection load='6bp0' size='340' side='right' caption='[[6bp0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
Authors: Counago, R.M., dos Reis, C.V., de Souza, G.P., Arruda, P., Edwards, A.M., Massirer, K.B., Elkins, J.M., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6bp0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BP0 FirstGlance]. <br>
-
Description: Crystal Structure of the Human vaccinia-related kinase 1 bound to pteridine inhibitor
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E1D:(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one'>E1D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-
[[Category: Elkins, J.M]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bp0 OCA], [http://pdbe.org/6bp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6bp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bp0 ProSAT]</span></td></tr>
-
[[Category: Edwards, A.M]]
+
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arruda, P]]
[[Category: Arruda, P]]
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
[[Category: Counago, R M]]
-
[[Category: Massirer, K.B]]
+
[[Category: Edwards, A M]]
-
[[Category: Counago, R.M]]
+
[[Category: Elkins, J M]]
-
[[Category: De Souza, G.P]]
+
[[Category: Massirer, K B]]
-
[[Category: Dos Reis, C.V]]
+
[[Category: Reis, C V.dos]]
 +
[[Category: Structural genomic]]
 +
[[Category: Souza, G P.de]]
 +
[[Category: Protein kinase domain]]
 +
[[Category: Sgc]]
 +
[[Category: Transferase]]
 +
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:26, 6 December 2017

Crystal Structure of the Human vaccinia-related kinase 1 bound to pteridine inhibitor

6bp0, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6bp0"
Personal tools